I’m happy to share that my perspective article, “Bacterial extracellular vesicles: From biotechnological tools to biological ‘black boxes’”, is now out in the 2026 issue of Trillium Extracellular Vesicles.

What the article is about
Bacterial EVs (bEVs) are being fast developed as drug-delivery vehicles, vaccine platforms (the OMV-based meningococcal vaccines are the best-known example) and diagnostic tools. Our understanding of their basic biology hasn’t kept up. We still don’t know how vesicles form, how cargo is selected, or why vesicle populations are so heterogeneous, especially in Gram-positive bacteria, where vesicles have to cross a thick cell wall. Differences in isolation methods and the lack of standardised markers also make studies hard to compare. This piece argues that resolving these mechanisms is essential for both fundamental microbiology and the medical potential of bEVs.

📄 Read the article: DOI 10.47184/tev.2026.01.03
📚 Browse the full issue: Trillium Extracellular Vesicles 2026

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